PUBLICATIONS

A Y chromosome-linked genome editor for efficient population suppression in the malaria vector Anopheles gambiae,
Tolosana I, Willis K, Gribble M et al.
NATURE COMMUNICATIONS // 02 January 2025.

Y chromosome shredding in Anopheles gambiae: Insight into the cellular dynamics of a novel synthetic sex ratio distorter,
Vitale M, Kranjic N, Leigh J et al.
PLOS GENETICS // 7 June 2024.

Single-cell profiling of Anopheles gambiae spermatogenesis defines the onset of meiotic silencing and premeiotic overexpression of the X chromosome,
Page N, Taxiarchi C, Tonge D et al.
NATURE COMMUNICATIONS BIOLOGY // 15 August 2023.

Whole-Mount Fluorescence In Situ Hybridization to Study Spermatogenesis in the Anopheles Mosquito,
Vitale M, Liang J, Sharakhov I et al.
JoVE JOURNAL // 26 May 2023.

CRISPR-Mediated Cassette Exchange (CriMCE): A Method to Introduce and Isolate Precise Marker-Less Edits,
Morianou I, Crisanti A, Nolan T et al.
THE CRISPR JOURNAL // 12 December 2022.

Driving down malaria transmission with engineered gene drives,
Garrood WT, Cuber P, Willis K et al.
FRONTIERS IN GENETICS // 19 October 2022.

Introgression of a synthetic sex ratio distortion transgene into different genetic backgrounds of Anopheles coluzzii,
Pollegioni P, Persampieri T, Minuz RL et al.
INSECT MOLECULAR BIOLOGY // 17 October 2022.

Infravec2 guidelines for the design and operation of containment level 2 and 3 insectaries in Europe,
Pondeville E, Failloux A, Simard F et al.
PATHOGENS AND GLOBAL HEALTH // 22 August 2022.

Comprehensive characterization of a transgene insertion in a highly repetitive, centromeric region of Anopheles mosquitoes,
Vitale M, Leo C, Courty T et al.
PATHOGENS AND GLOBAL HEALTH // 21 July 2022.

The Potential for a Released Autosomal X-Shredder Becoming a Driving-Y Chromosome and Invasively Suppressing Wild Populations of Malaria Mosquitoes,
Alcalay Y, Fuchs S, Galizi R et al.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY // 3 December 2021.

Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation,
Fuchs S, Garrood WT, Beber A et al.
PLOS GENETICS // 5 October 2021.

Gene-drive suppression of mosquito populations in large cages as a bridge between lab and field,
Hammond A, Pollegioni P, Persampieri T et al.
NATURE COMMUNICATIONS // 28 July 2021

A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppression,
Taxiarchi C, Beaghton A, Illansinhage Don, N et al.
NATURE COMMUNICATIONS // 25 June 2021.

Genetic Technologies for Sustainable Management of Insect Pests and Disease Vectors,
Grilli S, Galizi R, Taxiarchi, C.
SUSTAINABILITY // 18 May 2021.

Analysis of off-target effects in CRISPR-based gene drives in the human malaria mosquito,
Garrood WT, Kranjc N, Petri K et al.
PNAS // 30 April 2021.

Ultra-conserved sequences in the genomes of highly diverse Anopheles mosquitoes, with implications for malaria vector control,
O’Loughlin SM, Forster AJ, Fuchs S et al.
G3 // 17 March 2021.

A Code of Ethics for Gene Drive Research,
Annas GJ, Beisel CL, Clement K et al.
THE CRISPR JOURNAL // 19 February 2021.

Regulating the expression of gene drives is key to increasing their invasive potential and the mitigation of resistance,
Hammond A, Karlsson X, Morianou I et al.
PLOS GENETICS // 29 January 2021.

Anopheles gambiae Genome Conservation as a Resource for Rational Gene Drive Target Site Selection,
Kranjc N, Crisanti A, Nolan T et al.
INSECTS // 23 January 2021.

Standardizing the definition of gene drive,
Alphey LS, Crisanti A, Randazzo F et al.
PNAS // 18 November 2020.

Cellular mechanisms regulating synthetic sex ratio distortion in the Anopheles gambiae germline,
Haghighat-Khah RE, Sharma A, Wunderlich MR et al.
PATHOGENS AND GLOBAL HEALTH // 12 October 2020.

Assessing the acoustic behaviour of Anopheles gambiae (s.l.) dsxF mutants: implications for vector control,
Su MP, Georgiades M, Bagi J et al.
PARASITES & VECTORS // 7 October 2020.

Detecting the population dynamics of an autosomal sex ratio distorter transgene in malaria vector mosquitoes,
Pollegioni P, North AR, Persampieri T et al.
JOURNAL OF APPLIED ECOLOGY // 18 June 2020.

A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae,
Simoni A, Hammond AM, Beaghton AK et al.
NATURE BIOTECHNOLOGY // 11 May 2020.

Gene drive for population genetic control: non-functional resistance and parental effects,
Beaghton AK, Hammond A, Nolan T et al.
PROCEEDINGS OF THE ROYAL SOCIETY B // 30 October 2019.

High-resolution transcriptional profiling of Anopheles gambiae spermatogenesis reveals mechanisms of sex chromosome regulation,
Taxiarchi C, Kranjc N, Kriezis A et al.
NATURE SCIENTIFIC REPORTS // 16 October 2019.

Introgression of a synthetic sex ratio distortion system from Anopheles gambiae into Anopheles arabiensis,
Bernardini F, Kriezis A, Galizi R et al.
NATURE SCIENTIFIC REPORTS // 26 March 2019.

Large-cage assessment of a transgenic sex-ratio distortion strain on populations of an African malaria vector,
Facchinelli L, North AR, Collins CM et al.
PARASITES & VECTORS // 6 February 2019.

Molecular tools and genetic markers for the generation of transgenic sexing strains in Anopheline mosquitoes,
Bernardini F, Haghighat-Khah RE, Galizi R et al.
PARASITES & VECTORS // 24 December 2018.

A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes
Kyrou K, Hammond AM, Galizi R et al.
NATURE BIOTECHNOLOGY // 24 September 2018

Gene drives to fight malaria: current state and future directions,
Hammond AM and Galizi R.
PATHOGENS AND GLOBAL HEALTH // 19 February 2018.

Gene Drive: Evolved and Synthetic,
Burt A and Crisanti A.
ACS CHEMICAL BIOLOGY // 5 February 2018.

Gene drive to reduce malaria transmission in sub-Saharan Africa,
Burt A, Coulibaly M, Crisanti A et al.
JOURNAL OF RESPONSIBLE INNOVATION // 24 January 2018.

The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito,
Hammond AM, Kyrou K, Bruttini M et al.
PLOS GENETICS // 4 October 2017.

Cross-Species Y Chromosome Function Between Malaria Vectors of the Anopheles gambiae Species Complex,
Bernardini F, Galizi R, Wunderlich M et al.
GENETICS // 1 October 2017.

Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing,
Beaghton A, Hammond A, Nolan T et al.
GENETICS // 1 April 2017.

The Anopheles FBN9 immune factor mediates Plasmodium species-specific defense through transgenic fat body expression,
Simões ML, Dong Y, Hammond A et al.
DEVELOPMENTAL & COMPARATIVE IMMUNOLOGY // 22 September 2016.

Advancing vector biology research: a community survey for future directions, research applications and infrastructure requirements,
Kohl A, Pondeville E, Schnettler E et al.
PATHOGENS AND GLOBAL HEALTH // 11 August 2016.

A CRISPR-Cas9 sex-ratio distortion system for genetic control,
Galizi R, Hammond A, Kyrou K et al.
NATURE SCIENTIFIC REPORTS // 3 August 2016.

Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes,
Hall AB, Papathanos PA, Sharma A et al.
PNAS // 29 March 2016.

A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae,
Hammond A, Galizi R, Kyrou K et al.
NATURE BIOTECHNOLOGY // 1 January 2016

VEGF and LPS synergistically silence inflammatory response to Plasmodium berghei infection and protect against cerebral malaria,
Canavese M, Dottorini T, Crisanti A et al.
PATHOGENS AND GLOBAL HEALTH // 21 September 2015.

Vascular endothelial growth factor (VEGF) and lovastatin suppress the inflammatory response to Plasmodium berghei infection and protect against experimental cerebral malaria,
Canavese M and Crisanti A.
PATHOGENS AND GLOBAL HEALTH // 21 September 2015.

A draft genome sequence of an invasive mosquito: an Italian Aedes albopictus,
Dritsou V, Topalis P, Windbichler N et al.
PATHOGENS AND GLOBAL HEALTH // 14 September 2015.

Stimulating Anopheles gambiae swarms in the laboratory: application for behavioural and fitness studies,
Facchinelli L, Valerio L, Lees RS et al.
MALARIA JOURNAL // 15 July 2015.

Replication of Plasmodium in reticulocytes can occur without hemozoin formation, resulting in chloroquine resistance,
Lin JW, Spaccapelo R, Schwarzer E et al.
JOURNAL OF EXPERIMENTAL MEDICINE // 4 May 2015.

The germline of the malaria mosquito produces abundant miRNAs, endo-siRNAs, piRNAs and 29-nt small RNAs,
Castellano L, Rizzi E, Krell J et al.
BMC GENOMICS // 19 February 2015.

Development of synthetic selfish elements based on modular nucleases in Drosophila melanogaster,
Simoni A, Siniscalchi C, Chan YS et al.
NUCLEIC ACIDS RESEARCH // 11 February 2015.

Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes,
Neafsey D, Waterhouse RM, Abai MR et al.
SCIENCE // 27 November 2014.

Disruption of aminergic signalling reveals novel compounds with distinct inhibitory effects on mosquito reproduction, locomotor function and survival,
Fuchs S, Rende E, Crisanti A et al.
NATURE SCIENTIFIC REPORTS // 2 July 2014.

Development of synthetic selfish elements based on modular nucleases in Drosophila melanogaster,
Simoni A, Siniscalchi C, Chan YS et al.
NUCLEIC ACIDS RESEARCH // 17 June 2014.

A synthetic sex ratio distortion system for the control of the human malaria mosquito,
Galizi R, Doyle LA, Menichelli M et al.
NATURE COMMUNICATIONS // 10 June 2014.

Site-specific genetic engineering of the Anopheles gambiae Y chromosome,
Bernardini F, Galizi R, Menichelli M et al.
PNAS // 12 May 2014.

Phenylalanine Metabolism Regulates Reproduction and Parasite Melanization in the Malaria Mosquito,
Fuchs S, Behrends V, Bundy JG et al.
PLOS ONE // 7 January 2014.

Silencing of the Hsf gene, the transcriptional regulator of A. gambiae male accessory glands, inhibits the formation of the mating plug in mated females and disrupts their monogamous behaviour,
Dottorini T, Persampieri T, Palladino P et al.
PATHOGENS AND GLOBAL HEALTH // 12 November 2013.

CluGene: A Bioinformatics Framework for the Identification of Co-Localized, Co-Expressed and Co-Regulated Genes Aimed at the Investigation of Transcriptional Regulatory Networks from High-Throughput Expression Data,
Dottorini T, Palladino P, Senin N et al.
PLOS ONE // 18 June 2013.

Regulation of Anopheles gambiae male accessory gland genes influences postmating response in female,
Dottorini T, Persampieri T, Palladino P et al.
THE FASEB JOURNAL // 20 September 2012.

Demasculinization of the Anopheles gambiae X chromosome,
Magnusson K, Lycett GJ, Mendes AM et al.
BMC ECOLOGY AND EVOLUTION // 18 May 2012.

A New Threat Looming over the Mediterranean Basin: Emergence of Viral Diseases Transmitted by Aedes albopictus Mosquitoes,
Gasperi G, Bellini R, Malacrida AR et al.
PLOS NTD // 27 September 2012.

Mosquito Transgenic Technologies to Reduce Plasmodium Transmission,
Fuchs S, Nolan T and Crisanti A.
SPRINGER PROTOCOL: MALARIA // 25 August 2012.

Spermless males elicit large-scale female responses to mating in the malaria mosquito Anopheles gambiae,
Thailayil J, Magnusson K, Godfrey HCJ et al.
PNAS // 8 August 2011.

Transcription Regulation of Sex-Biased Genes during Ontogeny in the Malaria Vector Anopheles gambiae,
Magnusson K, Mendes AM, Windbichler N et al.
PLOS ONE // 30 June 2011.

A comprehensive gene expression atlas of sex- and tissue-specificity in the malaria vector, Anopheles gambiae,
Baker DA, Nolan T, Fischer B et al.
BMC GENOMICS // 7 June 2011.

A synthetic homing endonuclease-based gene drive system in the human malaria mosquito
Windbichler N, Menichelli M, Papathanos PA et al.
NATURE // 20 April 2011

Analysis of two novel midgut-specific promoters driving transgene expression in Anopheles stephensi mosquitoes,
Nolan T, Petris E, Müller HM et al.
PLOS ONE // 4 February 2011.

Gepoclu: a software tool for identifying and analyzing gene positional clusters in large-scale gene expression analysis,
Dottorini T, Senin N, Mazzoleni G et al.
SOFTWARE // 26 January 2011.

Developing transgenic Anopheles mosquitoes for the sterile insect technique,
Nolan T, Papathanos P, Windbichler N et al.
GENETICA // 7 September 2010.

Sex separation strategies: past experience and new approaches,
Papathanos PA, Bossin HC, Benedict MQ et al.
MALARIA JOURNAL // 16 November 2009.

The vasa regulatory region mediates germline expression and maternal transmission of proteins in the malaria mosquito Anopheles gambiae: a versatile tool for genetic control strategies,
Papathanos PA, Windbichler N, Menichelli M et al.
BMC MOLECULAR BIOLOGY // 2 July 2009.

Transgenic technologies to induce sterility,
Catteruccia F, Crisanti A and Wimmer EA.
MALARIA JOURNAL // 16 November 2009.

Targeting the X Chromosome during Spermatogenesis Induces Y Chromosome Transmission Ratio Distortion and Early Dominant Embryo Lethality in Anopheles gambiae,
Windbichler N, Papathanos PA and Crisanti A.
PLOS GENETICS // 5 December 2008.

Homing endonuclease mediated gene targeting in Anopheles gambiae cells and embryos,
Windbichler N, Papathanos PA, Catteruccia F et al.
NUCLEIC ACIDS RESEARCH // 1 September 2007.

A genome-wide analysis in Anopheles gambiae mosquitoes reveals 46 male accessory gland genes, possible modulators of female behavior,
Dottorini T, Nicolaides L, Ranson H et al.
PNAS // 15 August 2007.

An Anopheles transgenic sexing strain for vector control,
Catteruccia F, Benton JP and Crisanti A.
NATURE BIOTECHNOLOGY // 9 October 2005.

Identification of sex-specific transcripts of the Anopheles gambiae doublesex gene,
Scali C, Catteruccia F, Li Q et al.
JOURNAL OF EXPERIMENTAL BIOLOGY // 1 October 2005.

Stable and heritable gene silencing in the malaria vector Anopheles stephensi,
Brown AE, Bugeon L, Crisanti A et al.
NUCLEIC ACIDS RESEARCH // 1 August 2003.

Comparative analysis of DNA vectors at mediating RNAi in Anopheles mosquito cells and larvae,
Brown AE, Crisanti A and Catteruccia F.
JOURNAL OF EXPERIMENTAL BIOLOGY // 1 June 2003.

Impact of Genetic Manipulation on the Fitness of Anopheles stephensi Mosquitoes,
Catteruccia F, Godfray HCJ and Crisanti A.
SCIENCE // 21 February 2003.

Malaria Control with Genetically Manipulated Insect Vectors,
Alphey L, Beard CB, Billingsley P et al.
SCIENCE // 4 October 2002.

piggyBac-mediated Germline Transformation of the Malaria Mosquito Anopheles stephensi Using the Red Fluorescent Protein dsRED as a Selectable Marker,
Nolan T, Bower TM, Brown AE et al.
JOURNAL OF BIOLOGICAL CHEMISTRY // 1 March 2002.

Nuclear Factors Bind to a Conserved DNA Element That Modulates Transcription of Anopheles gambiae Trypsin Genes,
Giannoni F, Müller HM, Vizioli J et al.
JOURNAL OF BIOLOGICAL CHEMISTRY // 1 January 2001.

Stable germline transformation of the malaria mosquito Anopheles stephensi,
Catteruccia F, Nolan T, Loukeris TG et al.
NATURE // 22 June 2000.

Toward Anopheles transformation: Minos element activity in anopheline cells and embryos,
Catteruccia F, Nolan T, Blass C et al.
NATURE // 11 February 2000.

The A-domain and the thrombospondin-related motif of Plasmodium falciparum TRAP are implicated in the invasion process of mosquito salivary glands,
Wengelnik K, Spaccapelo R, Naitza S et al.
THE EMBO JOURNAL // 1 October 1999.